Diagnostic Aspects of Formation of A Protracted Course of Community-acquired Pneumonia in Children

Sarvinoz Khaydarova and Nurali Shavazi

Introduction. In the world of bronchopulmonary diseases, one of the unresolved problems of modern pediatrics remains. In the past 10 years, pneumonia has been a leader among these diseases. Community-acquired pneumonia is an acute disease that has occurred in community-acquired conditions, accompanied by symptoms of lower respiratory tract infection and fresh focal-infiltrative changes in the lungs. The aim of the study was to develop a differentiated treatment method for the protracted course of community-acquired pneumonia in children and to assess their effect on the cytokine status. Materials and methods. We analyzed 853 case histories of children treated in Prospectively; under our supervision, there were 123 children who were divided into group II. The first group included 65 children (community-acquired pneumonia (CAP) for a prolonged period), the second control group included 58 children (community-acquired pneumonia for an acute course). In the process of a comprehensive clinical and laboratory examination of children, biochemical, microbiological and immunological research methods were used. Enzyme-linked immunosorbent assay (determination of markers of interleukin-4.6, tumor necrosis factor-alpha) was carried out in a private clinic INNOVA in Samarkand, microbiological studies. Results. When studying the history of these children, a number of adverse factors were noted. Thus, 45.5% (56) of the mothers of the observed children had toxicosis of the first and second half of pregnancy, a miscarriage threat in 42.3% (52), and anemia I-II degree in 84.6% (104). In the main group, 21.5% of children were born in asphyxia, and 2.5 times less in the comparison group (8.6%; P <0.05). When analyzing the medical history, it was noted that premature birth among patients with community-acquired pneumonia was 4.9%: 6.2% in the main group and 3.4% in the comparison group. 57.5% (88) of the mothers had acute respiratory infections during pregnancy. Most mothers of children - 69.6% had foci of chronic infection. Laboratory data: Data showed that the level of interleukin-4 in children with community-acquired pneumonia was 2.3 times higher than the control, increasing to 10.8 ± 0.9 pg / ml (P <0.01), relative to the control group. Interleukin-6 was 13.4 ± 0.3 pg / ml and was 2 times higher than in the control group (p <0.05). Tumor necrosis factor-alpha up to 63.5 ± 3.2 pg / ml compared with the (P <0.01) control group. Conclusion. In order to correct the revealed changes, differentiated treatment regimens for children with community-acquired pneumonia have been developed and recommended. In the acute period of the disease, Bronchomunal P (3.5 mg) was prescribed 1 capsule / day until the symptoms of the disease disappeared, but not less than 10 days. With a prolonged course of the disease, 1 capsule / day for 1 month. In the next 2 months, the drug is used in 1 capsule for 10 days with a 20-day interval between courses.

Volume 12 | Issue 5

Pages: 147-156

DOI: 10.5373/JARDCS/V12I5/20201698